Join The Beam Team

Scientist I/II, In Vivo Hematology/ Immuno-Oncology

Directions to apply

Submit your resume to careers@beamtx.com

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We are currently seeking a self-motivated and technically competent research Scientist to join our team. He/She will support our exploratory research in disease target validation using gene editing tools in our hematology and immuno-oncology group. The candidate will be responsible for conducting preclinical animal studies to support the development of ex-vivo cellular therapies.  They will also perform downstream in-vitro assays.

 

Primary Responsibilities:

  • Manage 1-3 research associates to generate robust pharmacological and disease relevant biological data.
  • Design, plan, and execute in-vivo studies in immunodeficient mice for hematology and immuno-oncology
  • Support the implementation and validation of new animal models.
  • Perform in-vitro assays; including erythroid differentiation, colony forming assays, ELISA, flow cytometry, and qPCR.
  • Experience with cell culture in primary cells and cell lines.
  • Analyze data using software including FlowJo, Excel, and GraphPad Prism.
  • Follow IACUC protocols and standard operating procedures (SOPs).
  • Coordinate in vivo pharmacology research in a matrixed environment, as well as external academic collaborations and an extensive network of CROs.

 

Qualifications:

  • PhD with at least 2 years’ experience in the biotechnology or pharmaceutical industry or BS/MS with over 10 years of relevant experience.
  • Experience with immunodeficient mice is required; including animal handling, routine injections, and necropsy.
  • Working knowledge of immuno-oncology, chimeric antigen receptors (CAR), T cell-mediated cytotoxicity, and animal models of adoptive therapy is desirable.
  • Expertise working with in vivo animal models of engraftment.
  • Experience with ELISA, flow cytometry, and qPCR.
  • Experience with IVIS Imaging.
  • Experience with cell culture and sterile technique.
  • Desire and drive to learn and understand the basic biologic mechanisms underpinning our cell and gene therapy products.
  • Experience in maintaining a laboratory notebook and following protocols.
  • Familiarity with programs such as Excel, GraphPad Prism, FlowJo, and PowerPoint for data entry, analysis, and presentation.
  • Team player with excellent oral and written communication skills and “do-what-it-takes” attitude.
  • Independently motivated, detail-oriented, and excellent problem-solving abilities.
  • Excellent organizational skills towards multi-tasking in an extremely fast-paced environment with changing priorities.