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Scientist/Senior Scientist, Structural Bioinformatics

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We are seeking an innovative, collaborative and accomplished computational scientist to support the development of novel gene editing therapies using our next-generation, state-of-the-art technology. The individual in this position will play a key role in Beam’s protein engineering efforts by developing and deploying structural informatics methods to investigate structure-function relationships in base editor ribonucleoprotein complexes and propose sequence modifications to optimize their function.


Primary Responsibilities:

  • Perform structural analysis of proteins and ribonucleoproteins to identify key residues and regions of interest for engineering of CRISPR nucleases and other base editor domains
  • Use protein modeling software (e.g., Rosetta) to support the engineering of novel protein variants
  • Perform phylogenetic analyses to identify residues of interest and infer structure-function relationships
  • Use homology modeling to support the structural analysis of orthologous and engineered proteins
  • Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations and provide interpretable recommendations to scientific collaborators.


  • A Ph.D. in Bioinformatics, Structural Biology, Biophysics, or equivalent field
  • Industry experience is preferred
  • Strong scientific background and publication record demonstrating applications of structural analysis for protein engineering
  • Robust knowledge of Rosetta or other protein modeling software
  • Experience analyzing CRISPR/Cas9 proteins is ideal
  • Ability to work independently while also building relationships with colleagues