We are seeking an innovative, collaborative and accomplished computational scientist to support the development of novel gene editing therapies using our next-generation, state-of-the-art technology. The individual in this position will play a key role in Beam’s protein engineering efforts by developing and deploying structural informatics methods to investigate structure-function relationships in base editor ribonucleoprotein complexes and propose sequence modifications to optimize their function.
- Perform structural analysis of proteins and ribonucleoproteins to identify key residues and regions of interest for engineering of CRISPR nucleases and other base editor domains
- Use protein modeling software (e.g., Rosetta) to support the engineering of novel protein variants
- Perform phylogenetic analyses to identify residues of interest and infer structure-function relationships
- Use homology modeling to support the structural analysis of orthologous and engineered proteins
- Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations and provide interpretable recommendations to scientific collaborators.
- A Ph.D. in Bioinformatics, Structural Biology, Biophysics, or equivalent field
- Industry experience is preferred
- Strong scientific background and publication record demonstrating applications of structural analysis for protein engineering
- Robust knowledge of Rosetta or other protein modeling software
- Experience analyzing CRISPR/Cas9 proteins is ideal
- Ability to work independently while also building relationships with colleagues