Beam seeks an innovative, collaborative and accomplished computational scientist to support the development of novel gene editing therapies using our next-generation, state-of-the-art technology. The individual in this position will play a key role in Beam’s protein engineering efforts by developing and deploying computational modeling approaches to investigate and optimize base editors and other relevant proteins.
- Perform structural analysis of proteins and ribonucleoproteins to identify key residues and regions of interest for engineering of CRISPR nucleases and base editor domains.
- Deploy modeling software (e.g., Rosetta, Schrodinger suite, etc.) to evaluate engineering strategies and generate designs for improved base editors and other proteins of interest.
- Perform computational design and optimization of single-chain variable fragments (scFvs) and chimeric antigen receptors.
- Work closely with structural and synthetic biology teams to test computational hypotheses and models.
- Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations.
- A Ph.D. in Structural Biology, Biophysics, Chemistry, Biochemistry, or relevant field.
- Industry experience is preferred.
- Robust knowledge of computational modeling tools, particularly in the context of antibody engineering.
- Strong scientific background and publication record demonstrating applications of structural modeling.
- Ability to work independently while also building relationships with colleagues.