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Scientist/Sr. Scientist, Hematology

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We are looking for a highly motivated and creative Scientist with expertise in the cell and gene therapy space to help us advance our hematology programs through the use of precision engineering of hematopoietic stem and progenitor cells (HSPC). This position will be instrumental in developing and utilizing biologically relevant assays and model systems to advance our programs.  The ideal candidate will support our in vitro and in vivo efforts developing next-generation base editing technologies and will have extensive experience in stem cell biology.

Responsibilities:

  • Establish iPSC-based differentiation protocols to support the discovery and characterization of gene editing programs
  • Primary/stem cell (human CD34+, iPSC) isolation/purification, culture and functional characterization
  • Assist in designing, planning, and executing editing experiments with primary/stem cells (CD34+, iPSC)
  • Work with a cross-disciplinary team to optimize hematopoietic culture approaches
  • Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations

Qualifications:

  • Ph.D. in biological science or related discipline
  • Proven expertise in primary or stem cell culture [iPSC or HSPC experience a plus]
  • Strong scientific background and publication record with proven high levels of performance
  • Experience in HSPC-relevant experimental techniques, including both in vitro cellular assays and in vivo transplant models is highly desirable
  • Good understanding of gene editing tools and principles (ZFN, TALEN, CRISPR, or DNA base editors). Previous experience in gene editing is preferable but not required
  • Transcriptome analysis experience – bulk or single cell RNA-seq – is a plus
  • Excellent written communication skills and the ability to present effectively to teams with diverse scientific backgrounds
  • Ability to work independently while also building relationships with colleagues
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change and helps others manage through change