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Scientist/Sr. Scientist, Vector Production

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We are seeking an enthusiastic and accomplished scientist to contribute hands-on to manufacturing in-house research-grade rAAV vectors for in vitro and in vivo research studies. In this role, the scientist will be responsible for production scheduling, ordering, maintaining, and tracking critical plasmids and specialized reagents for the vector production group. The individual will participate in upstream and downstream processing of small- to medium-scale research-grade batches of rAAV vectors using multiple production systems. Since multiple novel AAV capsids will be evaluated, development of new production methods will be a key component of the work. This is an ideal position for an individual who is energetic and thrives in a team-oriented, fast-paced, and cross-disciplinary small biotech company environment.

Primary Responsibilities:

  • Produce rAAV vectors using triple transfection and baculovirus/sf9 systems.
  • Develop and optimize protocols for production of rAAV vectors using triple transfection and baculovirus/sf9 systems, especially for novel vectors.
  • Identify and apply effective resolutions to any technical challenges during upstream and downstream processes
  • Optimize multiple cell culture platforms for rAAV vector production including mammalian and insect cells
  • Ensure adequate use of electronic tracking system for documenting and tracking vector production requests, status and inventory
  • Order, maintain and track critical plasmids and specialized reagents for vector production group

 

Qualifications:

  • M.S. or Ph.D. in a biological science or chemical engineering (vectorology or bioprocessing focus) is required with minimum of 5-7 years of subsequent research, vector manufacturing, or process development experience
  • Minimum 2 years of relevant experience in the production of biologics with a focus on rAAV viral vectors (including familiarity with different rAAV production systems, especially triple transfection and baculovirus/sf9 systems)
  • Minimum 2 years of experience within a start-up or small biotech environment is ideal
  • Experience and knowledge of biologics and/or gene therapy vector manufacturing is strongly preferred
  • Excellent organizational skills and attention to detail
  • Ability to troubleshoot manufacturing issues and find timely solutions
  • Strong written and oral communication skills