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Scientist, Structural Biology

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We are seeking a highly skilled and innovative scientist to join our core structural biology unit that supports the development of novel gene editing proteins. The candidate should have a broad knowledge of protein biochemistry and deep experience in structural biology, ideally applied to gene editing proteins such as Cas or similar.

 

Primary Responsibilities:

  • Closely collaborate with the platform scientists to ensure the timely hypothesis-to-test cycle for the rapid discovery and optimization of novel editor variants
  • High-throughput crystallization screening, X-ray structure determination, and analysis of novel gene editing proteins
  • Cryo-EM grid preparation, managing cryo-EM data collection, structure determination and refinement of novel gene editing proteins
  • Earlier stage work including expression and purification of recombinant target proteins if necessary
  • Manage synchrotron X-ray and cryo-EM data collection through outsourcing or collaboration
  • Maintain structural biology infrastructure (e.g. Formulatrix instruments, Mosquito, Virtobot)
  • Proper electronic notebook record keeping and internal structure depository management
  • Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations

 

Qualifications:

  • A Ph.D. in Biochemistry, Molecular Biology or equivalent and a minimum of three years of experience with structural biology with related publications
  • Proven expertise in all aspects of protein X-ray crystallography is a must. Cryo-EM experience is not a must but will be a significant plus.
  • Proficiency in crystallographic program suites and molecular visualization programs
  • Experience in molecular biology techniques, protein purification, and protein engineering
  • Aptitude with detailed structural analyses and integration of structural observations into subsequent construct engineering and optimization
  • Experience with gene editing proteins (e.g. CRISPR/Cas9) will be a significant advantage
  • Ability to work independently while also building relationships with colleagues
  • Ability to adapt to increasing scope and complexity of work brought on by growth/change
  • Supervisory experience