Join The Beam Team

Scientist

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Beam is seeking a highly skilled and innovative scientist to join our Protein Sciences and Structural Biology unit that supports the development of novel gene editing proteins. The candidate should have a broad knowledge of protein biochemistry and deep experience in X-ray crystallography, ideally applied to gene editing proteins such as Cas9 or similar.

 

Primary Responsibilities:

  • Closely collaborate with the platform scientists to ensure the timely hypothesis-to-test cycle for the rapid discovery and optimization of novel gene editing enzymes and other therapeutically-relevant protein.
  • Develop in vitro biochemical assays to characterize novel base editor variants.
  • Build and execute high-throughput crystallography workflows for novel gene editing proteins, including sample preparation, crystallization screening, X-ray data acquisition and processing, and structure determination.
  • Earlier stage work, such as protein construct cloning, expression and purification of recombinant target proteins if necessary.
  • Communicate scientifically rigorous findings via verbal and written communications, visualizations, and presentations.

Qualifications:

  • A Ph.D. in Biochemistry, Structural Biology or equivalent and a minimum of three years of experience with crystallography with related publications.
  • Proven expertise in all aspects of protein X-ray crystallography is a must.
  • Familiarity with other structural biology techniques, such as Cryo-EM, is not a must but will be a significant plus.
  • Experience with gene editing proteins (e.g. Cas9) and/or DNA/RNA-protein complexes will be a significant advantage.
  • Experience in molecular biology techniques, protein purification, and protein engineering.
  • Broad knowledge and hands-on experience in biochemical assay development.
  • Aptitude with detailed structural analyses and integration of structural observations into subsequent construct engineering and optimization.
  • Experience in protein modeling and molecular dynamics will be favorably considered.
  • Strong communication skills, particularly the visual presentation of structural findings.