Beam seeks an experienced and highly motivated associate scientist to help advance our immunology platform, including allogeneic CAR-T programs. The ideal candidate will be a self-motivated, technically competent scientist that is energized to join a small, fast-moving team with a “can-do” attitude to moving science forward.
- Work in a highly collaborative, cross-functional group of scientists focused on creating advanced immune cell therapies in areas of need for patients.
- Apply base editor technologies to create engineered T cells with single and multiplex genomic edits for enhanced anti-cancer activity.
- Apply and critically evaluate base editor technologies in a wide array of immune cells.
- Execute experiments using relevant tumor models in vitro and in vivo using base edited cells.
- Human cell culture, including transformed cell lines and primary immune cells.
- Cell and molecular assays, including multi-color flow cytometry, cytotoxicity, and cytokine release.
- BS or MS in immunology, cancer biology, molecular biology or related discipline with 2+ years of experience.
- Expertise culturing human T cells transformed cell lines and using commonly used electroporation methods for the introduction of nucleic acids and proteins into these cells.
- Experience using emerging technologies such as high-throughput sequencing and droplet digital PCR.
- Experience with tumor models is preferred.
- Ability to design experiments, analyze data and interpret results independently and within a small, dynamic group of peers.
- Experience with molecular cloning techniques such as Gibson and USER assembly preferred.
- Intellectually curious attitude, and critical and creative thinking.