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Senior Research Associate, Molecular Biology and iPSC

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Beam seeks an experienced scientist to help us advance our New Opportunities programs, including precision therapeutic genome editing of patient-derived iPS and differentiated cells. The ideal candidate will support our in vitro efforts developing next-generation base editing technologies and will be a self-motivated, technically competent research associate that is energized to join a small, fast-moving team.

 

Primary Responsibilities:

  • Design and implement cloning strategies to construct plasmids used in gene editing experiments.
  • Transfection and downstream processing of model cell lines to assess editing at disease-relevant target loci.
  • Implement novel and established assays to assess large-scale genomic rearrangements and off-target effects of base editing technologies.
  • Maintain patient-derived iPS cell lines.
  • Employ established protocols to differentiate iPS cells into therapeutically-relevant cell types.
  • Generate novel genetic edits and phenotypically characterize the resulting cell populations.

 

Qualifications:

  • BS/MS in cell biology, molecular biology or related discipline with 2+ years’ experience in an academic or industry lab setting.
  • Experience culturing iPS cells is required.
  • Molecular cloning experience, including Gibson assembly and USER cloning, is preferred.
  • Ability to design experiments, analyze data and interpret results independently and within a small, dynamic group of peers.
  • Critical and creative thinking.
  • Experience using emerging technologies such as high-throughput sequencing and droplet digital PCR is a plus.