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Hematology

Principal Research Associate/Scientist, Hematology

  • Cambridge, MA
  • Added
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Position Overview:

Beam is seeking a highly motivated and detail-oriented PRA or Scientist to help advance our Hematology franchise. The scientist will lead early discovery effort on new hematology indications. An ideal candidate will be a team player who is scientifically curious, technically competent, collaborative and is able to multi-task in a fast-paced environment. 

Responsibilities:  

  • Designing, planning, and executing  in vitro and  in vivo studies with primary human CD34+ and murine HSPCs.
  • Culturing and manipulating cell lines and HSPCs from human and mouse primary sources and conducting  in vitro differentiation of primary HSPCs.
  • Performing multi-parameter flow cytometry.
  • Generating, analyzing and interpreting flow cytometry, NGS, RNA-seq and other data.
  • Coordinating and working with other groups at Beam in a highly matrixed environment, as well as external partners and CROs.
  • Presenting data and findings to internal scientific groups.
  • Maintain detailed documentation of experiments in ELN system.
  • Adapting to a fast-paced, dynamic research environment.
  • Contribute to the scientific strategy, discussion, and output of the team.
  • Living Beam Therapeutics core values of being part of a community of fearless innovators, being rigorous and honest in our research, listening with open minds, and committed to each other.

Qualifications:

  • PhD degree in biological sciences with 0-2 years’ experience or alternatively a Bachelor/Master’s degree in biological sciences with 10+ years’ experience.
  • Experience in the field of hematology or autoimmune disease with in vitro manipulation of primary human CD34+ and mouse HSCs is preferred.
  • Extensive cell culture experience, including experience culturing primary cells and iPS cells.
  • Proficiency in mammalian cell culture techniques, including cell line expansion, maintenance, cryopreservation and manipulation.
  • Experience with genome editing (e.g. CRISPR/Cas9) is desired.
  • Proficiency in assay development and receptor/kinase biology also desirable.
  • Experience with flow cytometry, qPCR, DNA and RNA extraction, transfection, electroporation, western blotting, ELISA is desired.
  • Experience with viral production and transduction is preferred.
  • Familiarity with programs such as Excel, GraphPad Prism, FlowJo, and other molecular biology software/tools for data entry and analysis as well as PowerPoint for presentation.
  • Team player with excellent oral and written communication skills.
  • Independently motivated, detail-oriented scientist with excellent critical thinking and problem-solving abilities.
  • Excellent organizational skills towards multi-tasking in an extremely fast-paced environment with changing priorities.


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