We seek a highly skilled and innovative scientist to join Beam’s platform technology development group. This position is focused on structural biology that supports the development and engineering of novel gene editing proteins. The candidate should have a deep understanding and experience in cryo-electron microscopy and X-ray crystallography methods and broad knowledge of protein biochemistry and biophysics.
- Independently design and execute cryo-EM and/or X-ray crystallography projects to study the mechanism of action for novel gene editing enzymes and other therapeutically relevant proteins
- Prepare cryo-EM grids, collect data, and determine the structures for the protein-protein or protein-DNA/RNA complexes of interest. Earlier stage work, including molecular cloning and protein production, will be carried out by other scientists, but the candidate may remain involved if a project-specific need arises
- Protein crystallization and structure determination of the proteins and protein-DNA/RNA complexes of interest.
- Lead or contribute to protein engineering and construct optimization by providing structural biology insights
- Closely collaborate with other platform scientists to drive the timely hypothesis-to-test cycle for the discovery and optimization of novel gene editing enzymes
- Communicate scientifically rigorous structural biology findings via verbal and written communications, visualizations, and presentations, mainly to non-structural biologists
- Maintain clear and accurate records of experimental methods and results
- A Ph.D. in Structural Biology, Biochemistry, Biophysics, or equivalent, with expertise in cryo-EM or X-ray crystallography
- Extensive knowledge in Structural biology, protein biochemistry, and protein engineering.
- Aptitude with detailed structural analyses and integration of structural observations into subsequent construct engineering and optimization
- Computational modeling experience is not a must but will be a significant plus
- Experience with gene editing proteins (e.g., CRISPR/Cas9) will be a significant advantage
- Demonstrated ability to work independently in a fast-paced and dynamic environment
- Ability to adapt to increasing scope and complexity of work brought on by growth/change