Company Overview:
Beam Therapeutics is a biotechnology company committed to establishing the leading, fully integrated platform for precision genetic medicines. To achieve this vision, Beam has assembled a platform that includes a suite of gene editing and delivery technologies and is in the process of building internal manufacturing capabilities. Beam’s suite of gene editing technologies is anchored by base editing, a proprietary technology that is designed to enable precise, predictable and efficient single base changes, at targeted genomic sequences, without making double-stranded breaks in the DNA. This has the potential to enable a wide range of potential therapeutic editing strategies that Beam is using to advance a diversified portfolio of base editing programs. Beam is a values-driven organization committed to its people, cutting-edge science, and a vision of providing life-long cures to patients suffering from serious diseases.
Position Overview:
Beam is seeking a highly skilled and motivated summer intern student to join our Analytical and Research Development Department from June through August 2025. The individual will be instrumental in supporting analytical method development and routine testing for the research and development programs, with a focus on antibody, nanobody, and lipid nanoparticle (LNP) characterization. This role involves developing analytical methods for in-depth structural characterization of LNP conjugates and performing quality control assessments of in-house proteins using advanced techniques such as liquid chromatography and mass spectrometry. Additionally, the student will contribute to the design and execution of forced degradation studies to assess product stability under various stress conditions. This position is essential to advancing Beam's programs from candidate selection to clinical development.
Responsibilities:
- Design and execute analytical assays for oligonucleotide and lipid molecules.
- Characterization of antibodies, nanobodies, and A1AT proteins using biochemical or biophysical methods.
- Purity and identity assessment of proteins via RP-HPLC and LC-MS.
- Assist in designing forced degradation studies and executing sample preparation to support clinical-stage drug development, using various biochemical and biophysical tools.
- Support identity method development for LNP conjugates using mass spectrometry, capillary electrophoresis, and flow-induced dispersion analysis.
Qualifications:
- Candidate must be pursuing a BS or MS in Pharmaceutical Sciences, Biomedical Science, Chemistry, or related field with at least 1 year of relevant laboratory experience.
- Previous experience with mass spectrometry and HPLC is a plus.
- Knowledge of analytical method development in drug discovery and development.
- Proficient in Excel, PowerPoint, ELN and data analysis is required.
- Excellent interpersonal and communication skills.
