Publications

DNA Base Editing

April 28, 2020 Nat Commun 11, 2052 (2020)

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Authors: Yu, Y., Leete, T.C., Born, D.A. et al

April 13, 2020 Nat Biotechnol 38, 892–900 (2020)

Directed evolution of adenine base editors with increased activity and therapeutic application

Authors: Gaudelli, N.M., Lam, D.K., Rees, H.A. et al.

January 14, 2020 Nature Biomedical Engineering

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

Authors: Jonathan M. Levy, Wei-Hsi Yeh, Nachiket Pendse, Jessie R. Davis, Erin Hennessey, Rossano Butcher, Luke W. Koblan, Jason Comander, Qin Liu & David R. Liu.

November 13, 2019 Blood

Complementary Base Editing Approaches for the Treatment of Sickle Cell Disease and Beta Thalassemia

Authors: Ling Lin, PhD , Adrian P. Rybak, PhD , Conrad Rinaldi, M.S. , Jonathan Yen, PhD , Yanfang Fu, PhD , Elsie Akrawi , Sarah Smith , Scott J....

October 15, 2018 Nature Reviews Genetics

Base editing: precision chemistry on the genome and transcriptome of living cells

Authors: Holly A. Rees and David R. Liu.

October 25, 2017 Nature

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Authors: Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer, Ahmed H. Badran, David I. Bryson, and David R. Liu.

August 30, 2017 Science Advances

Science Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Alexis C. Komor, Kevin T. Zhao, Michael S. Packer, Nicole M. Gaudelli, Amanda L. Waterbury, Luke W. Koblan, Y. Bill Kim, Ahmed H. Badran, and David R. Liu.

June 6, 2017 Nature

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Authors: Holly A. Rees, Alexis C. Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S. B. Edge, and David R. Liu.

February 13, 2017 Nature

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions.

Authors: Y. Bill Kim, Alexis C. Komor, Jonathan M. Levy, Michael S. Packer, Kevin T. Zhao, and David R. Liu.

May 19, 2016 Nature

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Authors: Alexis C. Komor, Y. Bill Kim, Michael S. Packer, John A. Zuris, and David R. Liu.

Prime Editing

October 29, 2019 Nature

Search-and-replace genome editing without double-strand breaks or donor DNA

Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis, Alexander A. Sousa, Luke W. Koblan, Jonathan M. Levy, Peter J. Chen, Christopher Wilson, Gregory A. Newby, Aditya Raguram & David...

RNA Base Editing

October 29, 2019 Science

A cytosine deaminase for programmable single-base RNA editing

Omar O. Abudayyeh, Jonathan S. Gootenberg, Brian Franklin, Jeremy Koob, Max J. Kellner, Alim Ladha, Julia Joung, Paul Kirchgatterer, David B. T. Cox, Feng Zhang

October 25, 2017 Science

RNA editing with CRISPR-Cas13

Authors: David B. T. Cox, Jonathan S. Gootenberg, Omar O. Abudayyeh, Brian Franklin, Max J. Kellner, Julia Joung, and Feng Zhang.

Nuclease Editing

October 29, 2019 Nature Communications

Engineering of CRISPR-Cas12b for human genome editing

Jonathan Strecker, Sara Jones, Balwina Koopal, Jonathan Schmid-Burgk, Bernd Zetsche, Linyi Gao, Kira S. Makarova, Eugene V. Koonin & Feng Zhang