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Publications

DNA Base Editing


April 28, 2020
Nat Commun 11, 2052 (2020)
Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Authors: Yu, Y., Leete, T.C., Born, D.A. et al

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April 13, 2020
Nat Biotechnol 38, 892–900 (2020)
Directed evolution of adenine base editors with increased activity and therapeutic application
Authors: Gaudelli, N.M., Lam, D.K., Rees, H.A. et al.

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January 14, 2020
Nature Biomedical Engineering
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
Authors: Jonathan M. Levy, Wei-Hsi Yeh, Nachiket Pendse, Jessie R. Davis, Erin Hennessey, Rossano Butcher, Luke W. Koblan, Jason Comander, Qin Liu & David R. Liu.

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November 13, 2019
Blood
Complementary Base Editing Approaches for the Treatment of Sickle Cell Disease and Beta Thalassemia
Authors: Ling Lin, PhD , Adrian P. Rybak, PhD , Conrad Rinaldi, M.S. , Jonathan Yen, PhD , Yanfang Fu, PhD , Elsie Akrawi , Sarah Smith , Scott J....

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October 15, 2018
Nature Reviews Genetics
Base editing: precision chemistry on the genome and transcriptome of living cells
Authors: Holly A. Rees and David R. Liu.

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October 25, 2017
Nature
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Authors: Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer, Ahmed H. Badran, David I. Bryson, and David R. Liu.

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August 30, 2017
Science Advances
Science Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
Alexis C. Komor, Kevin T. Zhao, Michael S. Packer, Nicole M. Gaudelli, Amanda L. Waterbury, Luke W. Koblan, Y. Bill Kim, Ahmed H. Badran, and David R. Liu.

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June 6, 2017
Nature
Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery
Authors: Holly A. Rees, Alexis C. Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S. B. Edge, and David R. Liu.

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February 13, 2017
Nature
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions.
Authors: Y. Bill Kim, Alexis C. Komor, Jonathan M. Levy, Michael S. Packer, Kevin T. Zhao, and David R. Liu.

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May 19, 2016
Nature
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
Authors: Alexis C. Komor, Y. Bill Kim, Michael S. Packer, John A. Zuris, and David R. Liu.

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Prime Editing


October 29, 2019
Nature
Search-and-replace genome editing without double-strand breaks or donor DNA
Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis, Alexander A. Sousa, Luke W. Koblan, Jonathan M. Levy, Peter J. Chen, Christopher Wilson, Gregory A. Newby, Aditya Raguram & David...

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RNA Base Editing


October 29, 2019
Science
A cytosine deaminase for programmable single-base RNA editing
Omar O. Abudayyeh, Jonathan S. Gootenberg, Brian Franklin, Jeremy Koob, Max J. Kellner, Alim Ladha, Julia Joung, Paul Kirchgatterer, David B. T. Cox, Feng Zhang

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October 25, 2017
Science
RNA editing with CRISPR-Cas13
Authors: David B. T. Cox, Jonathan S. Gootenberg, Omar O. Abudayyeh, Brian Franklin, Max J. Kellner, Julia Joung, and Feng Zhang.

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Nuclease Editing


October 29, 2019
Nature Communications
Engineering of CRISPR-Cas12b for human genome editing
Jonathan Strecker, Sara Jones, Balwina Koopal, Jonathan Schmid-Burgk, Bernd Zetsche, Linyi Gao, Kira S. Makarova, Eugene V. Koonin & Feng Zhang

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