ESCAPE
(BEAM-103)

ESCAPE (BEAM-103)

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The ESCAPE (Engineered Stem Cell Antibody Paired Evasion) platform is comprised of two components: BEAM-103, an anti-CD117 monoclonal antibody (mAb) that is designed to suppress and/or eliminate hematopoietic stem and progenitor cells that express CD117, and a cell therapy that includes a therapeutic edit, plus an additional edit to CD117 designed to prevent binding of BEAM-103, allowing the edited cells to function normally and evade targeting by the antibody. Together, this approach aims to provide a non-genotoxic alternative to traditional transplant myeloablative conditioning.